PCDH19

Across TCGA patient cohorts, PCDH19 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDH19-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and Cyclin-B1. Each is linked with PCDH19 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCDH19-to-partner and partner-to-PCDH19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PCDH19-low versus PCDH19-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH19→partner) and Y-score (partner→PCDH19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.956	+2.584	.002	.010	3	6
UCEC	eEF2 →	+0.208	+1.523	.011	.005	3	5
LUAD	Cyclin-B1 →	+0.517	+3.321	.013	.009	3	4
BRCA	MIG-6 →	+0.208	+2.326	<.001	.021	2	5
STAD	eIF4E →	+0.179	+2.584	.018	.010	3	3
STAD	GAPDH →	+0.415	+2.584	.003	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Caspase-7-cleavedD198 by PCDH19 expression — STAD

Explore this box plot interactively →