PCDH19

Across TCGA pan-cancer cohorts, PCDH19 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PCDH19 data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PCDH19 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PCDH19 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, THCA, and BRCA are the cancer types where PCDH19 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.767	0.599	<.001	72	view →
THCA	OS	Median	II,III,IV	0.755	0.984	<.001	56	view →
BRCA	DFS	Median	III,IV	0.877	0.711	<.001	52	view →
LUSC	OS	Quartile	All	0.762	0.556	<.001	50	view →
COAD	DFS	Tertile	II,III,IV	0.654	0.837	.003	24	view →
GBM	DFS	Quartile	All	0.425	0.190	.004	12	view →
DLBC	DFS	Median	All	1.000	0.620	.012	11	view →
ACC	OS	Median	III,IV	0.321	0.789	.011	9	view →
SKCM	OS	Median	II,III,IV	0.332	0.463	.026	9	view →
CHOL	OS	Quartile	All	1.000	0.213	.024	9	view →
UVM	OS	Tertile	III,IV	0.214	0.836	.011	9	view →
THYM	DFS	Quartile	II,III,IV	0.565	0.911	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PCDH19–KIRC (OS)

Open the KIRC breakdown →