PCDH19

Across TCGA cell cohorts, PCDH19 RNA expression is significantly associated with the go_rna of many other GO terms, with 853 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PCDH19-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, and mRNA splicing, via spliceosome. Each is linked with PCDH19 in more than 8 cancer types. Because this analysis shows association rather than direction, both PCDH19-to-partner and partner-to-PCDH19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via transesterification reactions grouped by PCDH19-low versus PCDH19-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH19→partner) and Y-score (partner→PCDH19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNA splicing, via transesterification reactions →	+0.037	+0.772	.002	.001	3	9
OVARY	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.060	+0.583	<.001	.004	3	9
OVARY	mRNA splicing, via spliceosome →	+0.060	+0.583	<.001	.004	3	9
BLOOD_Lymphoma	Regulation of heterochromatin organization →	+0.060	+0.010	<.001	.006	3	7
BREAST	Negative regulation of stem cell population maintenance →	+0.051	+0.438	.005	.008	3	7
BREAST	Regulation of microtubule-based process →	+0.038	+0.790	<.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 853 associations by consensus.

RNA splicing, via transesterification reactions by PCDH19 expression — OVARY

Explore this box plot interactively →