PCDH19

Across TCGA cell cohorts, PCDH19 mutation is significantly associated with the RNA expression of many other genes, with 1,181 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH19-associated genes across cancer lineages are IRF2, VPS4B, and TMEM241. Each is linked with PCDH19 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDH19-to-partner and partner-to-PCDH19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRF2 grouped by PCDH19-low versus PCDH19-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH19→partner) and Y-score (partner→PCDH19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IRF2 →	+0.821	+3.351	.001	.003	3	3
LARGE_INTESTINE	VPS4B →	+0.631	+1.949	.001	.002	3	3
LARGE_INTESTINE	TMEM241 →	+0.464	+3.169	.009	.006	3	3
LARGE_INTESTINE	ENOPH1 →	+0.482	+1.949	<.001	.002	3	3
BLOOD_Leukemia	SNTG2 →	+0.823	+3.977	.001	<.001	3	2
LARGE_INTESTINE	JOSD1 →	+0.421	+1.949	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,181 associations by consensus.

IRF2 by PCDH19 expression — BLOOD_Leukemia

Explore this box plot interactively →