Across TCGA patient cohorts, PCDH18 protein abundance is significantly associated with the RNA expression of many other genes, with 2,520 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDH18-associated genes across cancer lineages are TGFBI, KATNAL1, and SMC4. Each is linked with PCDH18 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDH18-to-partner and partner-to-PCDH18 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH18→partner) and Y-score (partner→PCDH18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TGFBI →	+1.572	+0.380	.006	.009	3	3
PDAC	KATNAL1 →	+0.627	+0.425	<.001	.003	3	2
LSCC	SMC4 →	-0.847	-0.392	.001	.006	3	2
PDAC	COL5A1 →	+1.288	+0.501	.001	.002	3	2
UCEC	RACGAP1 →	-0.694	-0.419	.001	<.001	3	2
PDAC	KLK4 →	+0.863	+0.363	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,520 associations by consensus.

Exploration

PCDH18 survival (RNA) · tumor vs normal (RNA) · all PCDH18 data types