PCDH17

Across TCGA cell cohorts, PCDH17 mutation is significantly associated with the RNA expression of many other genes, with 1,344 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH17-associated genes across cancer lineages are HHLA3, KCNAB3, and ACSM6. Each is linked with PCDH17 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDH17-to-partner and partner-to-PCDH17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA3 grouped by PCDH17-low versus PCDH17-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH17→partner) and Y-score (partner→PCDH17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HHLA3 →	+0.756	+2.129	.002	.001	3	3
LUNG_NSCLC_LUAD	KCNAB3 →	+0.932	+3.206	<.001	.006	3	3
SKIN	ACSM6 →	+0.028	+2.183	.002	.007	3	2
SKIN	PCSK5 →	+1.089	+3.064	.003	.009	3	2
LARGE_INTESTINE	KCTD17 →	+0.745	+3.321	.005	.002	3	2
LARGE_INTESTINE	PHF5A →	+0.520	+3.257	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,344 associations by consensus.

HHLA3 by PCDH17 expression — LARGE_INTESTINE

Explore this box plot interactively →