PCDH17

Across TCGA pan-cancer cohorts, PCDH17 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PCDH17 data layer compared with 9 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PCDH17 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCDH17 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRP, KIRC, and UVM are the cancer types where PCDH17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.786	0.919	<.001	144	view →
KIRC	DFS	Median	All	0.694	0.554	<.001	136	view →
UVM	DFS	Quartile	All	0.343	0.827	<.001	105	view →
STAD	OS	Quartile	All	0.499	0.691	.003	62	view →
UCS	OS	Median	IV	0.732	0.224	.018	42	view →
BLCA	OS	Median	II,III,IV	0.542	0.668	.005	40	view →
HNSC	DFS	Median	IV	0.667	0.480	.001	35	view →
LIHC	DFS	Tertile	All	0.455	0.593	.007	25	view →
LGG	OS	Median	All	0.941	0.832	<.001	24	view →
GBM	OS	Quartile	All	0.642	0.240	.006	18	view →
MESO	OS	Tertile	All	0.432	0.658	.013	15	view →
SCLC	OS	Tertile	IV	0.208	0.842	.024	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PCDH17–KIRP (DFS)

Open the KIRP breakdown →