PCDH15

Across TCGA patient cohorts, PCDH15 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,080 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PCDH15-associated GO terms across cancer lineages are Regulation of post-translational protein modification, Regulation of proteasomal protein catabolic process, and Peptidyl-lysine modification. Each is linked with PCDH15 in more than 17 cancer types. Because this analysis shows association rather than direction, both PCDH15-to-partner and partner-to-PCDH15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of post-translational protein modification grouped by PCDH15-low versus PCDH15-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH15→partner) and Y-score (partner→PCDH15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of post-translational protein modification →	+0.077	+0.068	<.001	<.001	3	18
STAD	Regulation of proteasomal protein catabolic process →	+0.078	+0.084	<.001	<.001	3	17
STAD	Peptidyl-lysine modification →	+0.071	+0.083	<.001	<.001	3	17
STAD	Positive regulation of TORC1 signaling →	+0.077	+0.069	<.001	<.001	3	17
STAD	Regulation of protein binding →	+0.069	+0.074	<.001	<.001	3	17
STAD	Epithelial tube formation →	+0.058	+0.071	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,080 associations by consensus.

Regulation of post-translational protein modification by PCDH15 expression — STAD

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