PCDH15

Across TCGA patient cohorts, PCDH15 mutation is significantly associated with the RNA expression of many other genes, with 9,873 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDH15-associated genes across cancer lineages are MCM10, UBE2T, and SPAG5. Each is linked with PCDH15 in more than 7 cancer types. Because this analysis shows association rather than direction, both PCDH15-to-partner and partner-to-PCDH15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM10 grouped by PCDH15-low versus PCDH15-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH15→partner) and Y-score (partner→PCDH15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM10 →	+0.723	+1.699	<.001	<.001	3	8
LUAD	UBE2T →	+0.710	+1.806	<.001	<.001	3	8
LUAD	SPAG5 →	+0.691	+1.584	<.001	<.001	3	7
UCEC	RAD51 →	+0.585	+1.242	<.001	<.001	3	7
LUAD	SPC25 →	+0.536	+1.216	<.001	<.001	3	7
LUAD	EME1 →	+0.617	+1.295	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,873 associations by consensus.

MCM10 by PCDH15 expression — LUAD

Explore this box plot interactively →