PCDH15

Across TCGA cell cohorts, PCDH15 mutation is significantly associated with the RNA expression of many other genes, with 2,456 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH15-associated genes across cancer lineages are ERI1, NUP107, and KRR1. Each is linked with PCDH15 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDH15-to-partner and partner-to-PCDH15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERI1 grouped by PCDH15-low versus PCDH15-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH15→partner) and Y-score (partner→PCDH15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ERI1 →	+0.639	+1.847	<.001	<.001	3	3
LARGE_INTESTINE	NUP107 →	+0.463	+1.847	.002	<.001	3	3
LARGE_INTESTINE	KRR1 →	+0.675	+2.584	.001	.001	3	3
LARGE_INTESTINE	NOP2 →	+0.628	+1.396	<.001	<.001	3	3
LARGE_INTESTINE	HELLS →	+0.907	+2.906	<.001	<.001	3	3
LARGE_INTESTINE	LYG1 →	+0.746	+1.396	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,456 associations by consensus.

ERI1 by PCDH15 expression — LARGE_INTESTINE

Explore this box plot interactively →