PCDH11X

Across TCGA patient cohorts, PCDH11X mutation is significantly associated with the RNA expression of many other genes, with 8,829 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDH11X-associated genes across cancer lineages are ZC3HC1, CDC45, and PDAP1. Each is linked with PCDH11X in more than 5 cancer types. Because this analysis shows association rather than direction, both PCDH11X-to-partner and partner-to-PCDH11X results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZC3HC1 grouped by PCDH11X-low versus PCDH11X-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH11X→partner) and Y-score (partner→PCDH11X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZC3HC1 →	+0.246	+1.232	<.001	<.001	3	6
LUAD	CDC45 →	+0.729	+2.643	<.001	<.001	3	6
UCEC	PDAP1 →	+0.250	+1.519	.001	<.001	3	6
LUAD	PRPF19 →	+0.261	+1.655	<.001	<.001	3	6
LUSC	PDCD2L →	+0.353	+1.068	<.001	<.001	3	6
UCEC	CCT7 →	+0.346	+1.577	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,829 associations by consensus.

ZC3HC1 by PCDH11X expression — UCEC

Explore this box plot interactively →