PCDH11X

Across TCGA pan-cancer cohorts, PCDH11X RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PCDH11X data layer compared with 7 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher PCDH11X RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCDH11X expression acts as an unfavorable survival marker, although some lineages such as LGG and ESCA show a favorable association.

UVM, UCEC, and LGG are the cancer types where PCDH11X RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.330	0.689	<.001	89	view →
UCEC	DFS	Quartile	II,III,IV	0.348	0.749	<.001	78	view →
LGG	DFS	Median	All	0.808	0.667	<.001	46	view →
ESCA	DFS	Tertile	II,III,IV	0.550	0.263	.003	34	view →
THCA	OS	Tertile	III,IV	0.795	0.958	.007	26	view →
KIRP	DFS	Quartile	III,IV	0.204	0.631	.004	24	view →
KICH	OS	Tertile	III,IV	0.162	0.808	.001	21	view →
COAD	OS	Tertile	III,IV	0.224	0.624	.022	21	view →
LUAD	DFS	Median	All	0.841	0.754	.009	16	view →
LUSC	OS	Median	IV	0.255	0.851	.021	12	view →
LIHC	DFS	Tertile	All	0.174	0.461	.003	9	view →
READ	DFS	Tertile	IV	0.095	0.697	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PCDH11X–UVM (DFS)

Open the UVM breakdown →