PCDH11X

Across TCGA patient cohorts, PCDH11X mutation is significantly associated with the total protein of many other genes, with 104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDH11X-associated genes across cancer lineages are mTOR_pS2448, Claudin-7, and Cyclin-B1. Each is linked with PCDH11X in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDH11X-to-partner and partner-to-PCDH11X results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PCDH11X-low versus PCDH11X-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH11X→partner) and Y-score (partner→PCDH11X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	mTOR_pS2448 →	-0.098	-1.752	.046	.012	3	5
ESCA	Claudin-7 →	+0.609	+2.999	.023	.023	3	4
READ	Cyclin-B1 →	+0.543	+3.035	.038	.014	2	5
UCEC	4E-BP1 →	+0.260	+1.766	<.001	<.001	3	4
LUAD	Cyclin-E2 →	+0.117	+1.186	.001	.010	3	4
BLCA	ATM →	-0.538	-2.321	.003	.035	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

mTOR_pS2448 by PCDH11X expression — COAD

Explore this box plot interactively →