PCDH11X

Across TCGA cell cohorts, PCDH11X mutation is significantly associated with the RNA expression of many other genes, with 632 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH11X-associated genes across cancer lineages are SOX14, DHX36, and ZNF451. Each is linked with PCDH11X in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDH11X-to-partner and partner-to-PCDH11X results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOX14 grouped by PCDH11X-low versus PCDH11X-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH11X→partner) and Y-score (partner→PCDH11X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SOX14 →	+0.293	+3.392	<.001	.007	3	2
LUNG_NSCLC_LUAD	DHX36 →	+0.605	+3.376	<.001	.002	3	2
LUNG_NSCLC_LUAD	ZNF451 →	+0.549	+3.431	.003	.002	3	2
LUNG_NSCLC_LUAD	BRDT →	+1.475	+2.877	<.001	.002	3	2
LUNG_NSCLC_LUAD	CRLF3 →	+0.530	+3.358	.001	.003	3	2
LARGE_INTESTINE	RPA2 →	+0.494	+2.829	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 632 associations by consensus.

SOX14 by PCDH11X expression — OESOPHAGUS

Explore this box plot interactively →