PCCB

Across TCGA cell cohorts, PCCB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,359 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PCCB-associated GO terms across cancer lineages are Regulation of translational fidelity, Amino acid metabolic process, and External encapsulating structure organization. Each is linked with PCCB in more than 14 cancer types. Because this analysis shows association rather than direction, both PCCB-to-partner and partner-to-PCCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational fidelity grouped by PCCB-low versus PCCB-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCCB→partner) and Y-score (partner→PCCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of translational fidelity →	+0.088	+1.158	.008	<.001	3	15
URINARY_TRACT	Amino acid metabolic process →	+0.081	+1.220	<.001	<.001	3	15
LUNG_NSCLC_LUSC	External encapsulating structure organization →	-0.134	-0.834	.004	.003	3	14
BLOOD_Leukemia	Porphyrin-containing compound biosynthetic process →	+0.105	+0.787	<.001	<.001	3	13
BLOOD_Leukemia	Tetrapyrrole biosynthetic process →	+0.105	+0.787	<.001	<.001	3	13
URINARY_TRACT	Aminoacyl-tRNA metabolism involved in translational fidelity →	+0.110	+0.925	.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,359 associations by consensus.

Regulation of translational fidelity by PCCB expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →