PCCA

Across TCGA pan-cancer cohorts, PCCA Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PCCA data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PCCA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PCCA expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

UVM, SKCM, and BLCA are the cancer types where PCCA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.213	0.718	.002	27	view →
SKCM	OS	Median	All	0.179	0.781	<.001	9	view →
BLCA	DFS	Median	II,III,IV	1.000	0.327	.046	4	view →
UCEC	OS	Median	All	0.965	0.652	.035	4	view →
COAD	OS	Median	All	0.547	0.872	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PCCA–UVM (OS)

Open the UVM breakdown →