PCCA

Across TCGA pan-cancer cohorts, PCCA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PCCA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PCCA RNA is repressed in tumor relative to normal tissue. In most cancer types PCCA is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where PCCA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCCA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−1.428	<.001	12	view →
THCA	Male	III,IV	−0.928	<.001	11	view →
KIRP	Male	III,IV	−1.423	<.001	10	view →
HNSC	Male	II,III,IV	−0.730	<.001	10	view →
KICH	Female	II,III,IV	−1.668	<.001	8	view →
LUSC	All	III,IV	−0.846	<.001	8	view →
BLCA	Male	All	−0.649	<.001	7	view →
BRCA	All	All	−0.896	<.001	6	view →
STAD	Female	All	−0.782	.003	4	view →
COAD	Female	All	−0.692	<.001	4	view →
LIHC	All	II,III,IV	−0.435	.018	4	view →
LUAD	All	IV	−0.860	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PCCA–KIRC

Open the KIRC breakdown →