PCCA

Across TCGA patient cohorts, PCCA protein abundance is significantly associated with the RNA expression of many other genes, with 12,486 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PCCA-associated genes across cancer lineages are NCAPH, KIF20A, and CENPL. Each is linked with PCCA in more than 7 cancer types. Because this analysis shows association rather than direction, both PCCA-to-partner and partner-to-PCCA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCCA versus NCAPH in BRCA, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCCA→partner) and Y-score (partner→PCCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCAPH →	-0.780	-0.390	<.001	<.001	3	8
BRCA	KIF20A →	-0.921	-0.380	<.001	<.001	3	7
GBM	CENPL →	-0.572	-0.384	<.001	<.001	3	7
OV	CENPO →	-0.642	-0.421	<.001	.001	3	7
BRCA	PRR11 →	-0.857	-0.363	<.001	<.001	3	7
COAD	WDR76 →	-0.796	-0.442	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,486 associations by consensus.

PCCA vs NCAPH — BRCA

Explore this scatter interactively →