PCCA

Across TCGA patient cohorts, PCCA mutation is significantly associated with the RNA expression of many other genes, with 2,763 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCCA-associated genes across cancer lineages are TRIAP1P1, HIRIP3, and NTAN1. Each is linked with PCCA in more than 2 cancer types. Because this analysis shows association rather than direction, both PCCA-to-partner and partner-to-PCCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIAP1P1 grouped by PCCA-low versus PCCA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCCA→partner) and Y-score (partner→PCCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRIAP1P1 →	+0.146	+6.108	<.001	.001	3	3
UCEC	HIRIP3 →	+0.459	+2.069	<.001	<.001	3	2
UCEC	NTAN1 →	+0.578	+4.201	<.001	<.001	3	2
UCEC	MRPL17 →	+0.295	+1.928	.002	.008	3	2
UCEC	PEF1 →	+0.295	+3.786	.001	<.001	3	2
UCEC	H2AZ1 →	+0.497	+1.809	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,763 associations by consensus.

TRIAP1P1 by PCCA expression — LUAD

Explore this box plot interactively →