PCCA

Across TCGA cell cohorts, PCCA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,855 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PCCA-associated GO terms across cancer lineages are Branched-chain amino acid metabolic process, Succinyl-CoA biosynthetic process, and Short-chain fatty acid catabolic process. Each is linked with PCCA in more than 17 cancer types. Because this analysis shows association rather than direction, both PCCA-to-partner and partner-to-PCCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Branched-chain amino acid metabolic process grouped by PCCA-low versus PCCA-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCCA→partner) and Y-score (partner→PCCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Branched-chain amino acid metabolic process →	+0.130	+1.275	<.001	<.001	3	18
PANCREAS	Succinyl-CoA biosynthetic process →	+0.137	+1.119	<.001	<.001	3	17
LUNG_NSCLC_LUAD	Short-chain fatty acid catabolic process →	+0.199	+1.098	<.001	<.001	3	15
SOFT_TISSUE	Acyl-CoA biosynthetic process →	+0.066	+1.139	<.001	<.001	3	13
LUNG_NSCLC_LUAD	Short-chain fatty acid metabolic process →	+0.167	+1.009	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Succinyl-CoA metabolic process →	+0.118	+1.130	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,855 associations by consensus.

Branched-chain amino acid metabolic process by PCCA expression — BREAST

Explore this box plot interactively →