PCCA

Across TCGA cell cohorts, PCCA mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCCA-associated genes across cancer lineages are TBPL2, OR13J1, and LY86. Each is linked with PCCA in more than 1 cancer types. Because this analysis shows association rather than direction, both PCCA-to-partner and partner-to-PCCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBPL2 grouped by PCCA-low versus PCCA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCCA→partner) and Y-score (partner→PCCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TBPL2 →	+0.111	+4.044	<.001	.004	3	2
CNS	OR13J1 →	+0.052	+4.222	<.001	.002	3	2
LARGE_INTESTINE	LY86 →	+0.055	+3.965	<.001	<.001	3	1
LARGE_INTESTINE	MUC5B →	+2.128	+3.160	<.001	.006	3	1
LARGE_INTESTINE	KLHDC7B →	+0.792	+3.707	<.001	.001	3	1
LARGE_INTESTINE	IPO8 →	+0.697	+3.064	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

TBPL2 by PCCA expression — BLOOD_Leukemia

Explore this box plot interactively →