PCCA-DT

Across TCGA pan-cancer cohorts, PCCA-DT RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PCCA-DT data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PCCA-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCCA-DT expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRP show a favorable association.

ACC, KICH, and UCEC are the cancer types where PCCA-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.131	0.766	<.001	104	view →
KICH	OS	Tertile	All	0.621	1.000	<.001	90	view →
UCEC	DFS	Quartile	III,IV	0.962	0.763	<.001	72	view →
SKCM	DFS	Tertile	All	0.674	0.789	.001	57	view →
KIRC	DFS	Tertile	III,IV	0.549	0.721	.006	53	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	47	view →
LIHC	OS	Tertile	All	0.423	0.618	<.001	42	view →
LGG	DFS	Tertile	All	0.749	0.877	<.001	33	view →
KIRP	DFS	Tertile	III,IV	0.791	0.168	.006	32	view →
BRCA	DFS	Median	III,IV	0.722	0.866	.001	23	view →
COAD	DFS	Median	All	0.706	0.850	.001	21	view →
CHOL	DFS	Quartile	II,III,IV	0.154	0.690	.010	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PCCA-DT–ACC (DFS)

Open the ACC breakdown →