PCCA-AS1

Across TCGA pan-cancer cohorts, PCCA-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated PCCA-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher PCCA-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCCA-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and UCS show a favorable association.

UVM, TGCT, and CESC are the cancer types where PCCA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.267	0.696	<.001	64	view →
TGCT	DFS	Median	II,III,IV	0.711	0.996	.022	24	view →
CESC	DFS	Tertile	III,IV	0.552	0.793	.020	22	view →
ACC	OS	Median	All	0.310	0.834	<.001	19	view →
MESO	OS	Quartile	All	0.793	0.206	.019	18	view →
UCS	OS	Tertile	IV	1.000	0.293	.035	18	view →
BLCA	DFS	Quartile	IV	0.319	0.157	.015	12	view →
ESCA	DFS	Quartile	II,III,IV	0.413	0.612	.027	12	view →
GBM	OS	Quartile	All	0.630	0.340	.011	8	view →
READ	OS	Quartile	II,III,IV	0.880	0.473	.013	8	view →
THCA	DFS	Quartile	IV	0.322	0.886	.002	7	view →
SARC	DFS	Quartile	All	0.421	0.644	.005	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

PCCA-AS1–UVM (DFS)

Open the UVM breakdown →