PCCA-AS1

Across TCGA pan-cancer cohorts, PCCA-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PCCA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PCCA-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PCCA-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and PRAD are the cancer types where PCCA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCCA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.153	<.001	8	view →
KICH	All	All	−0.152	<.001	5	view →
PRAD	All	All	+0.218	.039	2	view →
LUSC	Female	II,III,IV	−0.209	.030	2	view →
BRCA	All	III,IV	−0.203	.016	2	view →
CHOL	All	All	+0.257	.015	1	view →
BLCA	Female	III,IV	+0.158	.044	1	view →
KIRC	All	IV	−0.083	.037	1	view →
LIHC	All	All	+0.042	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PCCA-AS1–THCA

Open the THCA breakdown →