PCBP4

Across TCGA cell cohorts, PCBP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,378 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PCBP4-associated GO terms across cancer lineages are Regulation of smoothened signaling pathway, Postsynaptic density protein 95 clustering, and Regulation of G1/S transition of mitotic cell cycle. Each is linked with PCBP4 in more than 9 cancer types. Because this analysis shows association rather than direction, both PCBP4-to-partner and partner-to-PCBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of smoothened signaling pathway grouped by PCBP4-low versus PCBP4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCBP4→partner) and Y-score (partner→PCBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of smoothened signaling pathway →	+0.061	+1.483	.002	.001	2	10
LUNG_NSCLC_LUSC	Postsynaptic density protein 95 clustering →	+1.420	+2.011	.002	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of G1/S transition of mitotic cell cycle →	+0.058	+1.203	.002	.006	3	9
BONE	Actin filament depolymerization →	+0.200	+2.084	<.001	<.001	3	9
SOFT_TISSUE	Microtubule polymerization or depolymerization →	+0.074	+0.952	<.001	<.001	3	9
KIDNEY	Regulation of cell cycle G1/S phase transition →	+0.054	+1.143	.002	.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,378 associations by consensus.

Regulation of smoothened signaling pathway by PCBP4 expression — LUNG_NSCLC_LUSC

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