PCBP4

Across TCGA pan-cancer cohorts, PCBP4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PCBP4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PCBP4 RNA is repressed in tumor relative to normal tissue. In most cancer types PCBP4 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where PCBP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCBP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.783	<.001	11	view →
COAD	Female	All	+1.177	<.001	10	view →
LIHC	Female	II,III,IV	+2.141	<.001	9	view →
UCEC	All	II,III,IV	+1.359	<.001	6	view →
BRCA	Female	II,III,IV	−0.328	<.001	6	view →
STAD	Male	II,III,IV	+0.949	<.001	5	view →
LUSC	All	All	−0.362	<.001	5	view →
CHOL	Male	All	+2.403	<.001	3	view →
THCA	All	All	+0.320	<.001	2	view →
KICH	Female	II,III,IV	+0.455	.023	1	view →
HNSC	All	III,IV	+0.358	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PCBP4–KIRC

Open the KIRC breakdown →