Across TCGA patient cohorts, PCA3 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,574 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PCA3-associated proteins across cancer lineages are PRUNE2_S1842, PRUNE2, and PRUNE2_S699. Each is linked with PCA3 in more than 7 cancer types. Because this analysis shows association rather than direction, both PCA3-to-partner and partner-to-PCA3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PCA3→partner) and Y-score (partner→PCA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRUNE2_S1842 →	+1.189	+0.807	<.001	<.001	3	8
CCRCC	PRUNE2 →	+0.623	+1.185	<.001	<.001	3	6
CCRCC	PRUNE2_S699 →	+1.571	+1.654	<.001	.001	3	6
LUAD	PRUNE2_S918 →	+1.500	+1.120	<.001	<.001	3	6
LUAD	PRUNE2_S1788 →	+1.375	+0.924	<.001	<.001	3	5
HNSC	PRUNE2_S2866 →	+1.043	+1.028	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,574 associations by consensus.

Exploration

PCA3 survival (RNA) · tumor vs normal (RNA) · all PCA3 data types