Across TCGA pan-cancer cohorts, PCA3 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated PCA3 data layer.
The strongest signal is observed in cholangiocarcinoma (CHOL), where higher PCA3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PCA3 expression acts as an unfavorable survival marker, although some lineages such as KIRP and CESC show a favorable association.
CHOL, KIRP, and BRCA are the cancer types where PCA3 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.