PBXIP1

Across TCGA pan-cancer cohorts, PBXIP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PBXIP1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PBXIP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PBXIP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where PBXIP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.521	0.934	.002	14	view →
CCRCC	OS	Median	II,III,IV	0.339	1.000	.003	13	view →
PDAC	OS	Tertile	II,III,IV	0.541	0.269	.012	10	view →
HNSC	OS	Median	II,III,IV	0.933	0.992	.024	8	view →
LUAD	OS	Quartile	All	0.929	0.693	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PBXIP1–LSCC (OS)

Open the LSCC breakdown →