PBXIP1

Across TCGA pan-cancer cohorts, PBXIP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PBXIP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PBXIP1 RNA is repressed in tumor relative to normal tissue. In most cancer types PBXIP1 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, LIHC, and BLCA are the cancer types where PBXIP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PBXIP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.547	<.001	10	view →
LIHC	Female	II,III,IV	+1.238	<.001	9	view →
BLCA	Male	III,IV	−2.145	<.001	8	view →
COAD	Female	II,III,IV	−1.050	<.001	8	view →
UCEC	All	All	−1.045	<.001	6	view →
LUSC	Male	All	−0.819	<.001	6	view →
THCA	Male	II,III,IV	−0.810	.001	4	view →
BRCA	All	II,III,IV	−0.376	<.001	4	view →
CHOL	Male	All	+2.500	<.001	3	view →
READ	All	All	−1.111	.012	2	view →
LUAD	All	IV	−1.024	.048	2	view →
HNSC	Female	All	+0.686	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PBXIP1–KICH

Open the KICH breakdown →