PBXIP1

Across TCGA patient cohorts, PBXIP1 mutation is significantly associated with the RNA expression of many other genes, with 2,799 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBXIP1-associated genes across cancer lineages are MTFP1, MIR4441, and EDC3. Each is linked with PBXIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PBXIP1-to-partner and partner-to-PBXIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTFP1 grouped by PBXIP1-low versus PBXIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBXIP1→partner) and Y-score (partner→PBXIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTFP1 →	+0.625	+3.711	<.001	<.001	3	3
BRCA	MIR4441 →	+0.346	+5.096	.003	.008	3	2
UCEC	EDC3 →	+0.411	+2.839	<.001	.001	3	2
UCEC	MRPS11 →	+0.546	+3.333	<.001	<.001	3	2
UCEC	SHMT2 →	+0.678	+2.087	<.001	.006	3	2
UCEC	PGP →	+0.467	+3.247	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,799 associations by consensus.

MTFP1 by PBXIP1 expression — UCEC

Explore this box plot interactively →