PBXIP1

Across TCGA cell cohorts, PBXIP1 mutation is significantly associated with the RNA expression of many other genes, with 240 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PBXIP1-associated genes across cancer lineages are MLN, RBP2, and HAO2. Each is linked with PBXIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PBXIP1-to-partner and partner-to-PBXIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MLN grouped by PBXIP1-low versus PBXIP1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBXIP1→partner) and Y-score (partner→PBXIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MLN →	+0.071	+5.169	<.001	.005	3	1
BLOOD_Leukemia	RBP2 →	+0.034	+2.774	.001	.006	3	1
BLOOD_Leukemia	HAO2 →	+0.028	+2.971	.002	.003	3	1
BLOOD_Leukemia	DSPP →	+0.054	+3.318	.004	.007	3	1
BLOOD_Leukemia	LCN1 →	+0.025	+3.185	<.001	.006	3	1
BLOOD_Leukemia	PRM3 →	+0.033	+3.984	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 240 associations by consensus.

MLN by PBXIP1 expression — BREAST

Explore this box plot interactively →