PBX4

Across TCGA patient cohorts, PBX4 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBX4-associated genes across cancer lineages are beta-Catenin, Fibronectin, and FoxM1. Each is linked with PBX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PBX4-to-partner and partner-to-PBX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, beta-Catenin grouped by PBX4-low versus PBX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX4→partner) and Y-score (partner→PBX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	beta-Catenin →	+0.543	+2.321	.032	.035	3	2
UCEC	Fibronectin →	-0.342	-2.321	.039	.035	3	1
UCEC	FoxM1 →	+0.260	+2.817	.045	.036	3	1
UCEC	FOXO3a →	+0.173	+2.335	<.001	.020	3	1
UCEC	NF2 →	+0.355	+2.999	.001	.035	3	1
UCEC	p62 Lck ligand →	+0.548	+3.179	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

beta-Catenin by PBX4 expression — UCEC

Explore this box plot interactively →