PBX4

Across TCGA cell cohorts, PBX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,098 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PBX4-associated GO terms across cancer lineages are Negative regulation of mRNA splicing, via spliceosome, Negative regulation of mRNA processing, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with PBX4 in more than 10 cancer types. Because this analysis shows association rather than direction, both PBX4-to-partner and partner-to-PBX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA splicing, via spliceosome grouped by PBX4-low versus PBX4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX4→partner) and Y-score (partner→PBX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of mRNA splicing, via spliceosome →	+0.117	+1.663	<.001	<.001	3	11
BREAST	Negative regulation of mRNA processing →	+0.113	+1.736	<.001	<.001	3	11
URINARY_TRACT	Negative regulation of transcription initiation by RNA polymerase II →	+0.141	+1.953	<.001	<.001	3	11
URINARY_TRACT	U2-type prespliceosome assembly →	+0.086	+1.270	.001	.006	3	11
URINARY_TRACT	Negative regulation of DNA-templated transcription initiation →	+0.141	+1.953	<.001	<.001	3	11
BONE	Microtubule polymerization →	+0.095	+1.556	.006	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,098 associations by consensus.

Negative regulation of mRNA splicing, via spliceosome by PBX4 expression — BREAST

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