PBX4

Across TCGA cell cohorts, PBX4 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PBX4-associated genes across cancer lineages are CDX4 and RNASE11. Each is linked with PBX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PBX4-to-partner and partner-to-PBX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDX4 grouped by PBX4-low versus PBX4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX4→partner) and Y-score (partner→PBX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDX4 →	+0.007	+3.217	.001	.006	3	1
LARGE_INTESTINE	RNASE11 →	+0.018	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CDX4 by PBX4 expression — LARGE_INTESTINE

Explore this box plot interactively →