Across TCGA patient cohorts, PBX1 mutation is significantly associated with the RNA expression of many other genes, with 2,856 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBX1-associated genes across cancer lineages are RN7SKP181, RNU4-15P, and LDHAP7. Each is linked with PBX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PBX1-to-partner and partner-to-PBX1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX1→partner) and Y-score (partner→PBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP181 →	+0.156	+5.685	<.001	.003	3	3
BLCA	RNU4-15P →	+0.535	+6.147	<.001	.002	3	2
UCEC	LDHAP7 →	+0.846	+1.869	<.001	.005	3	2
UCEC	MTMR12 →	+0.521	+2.736	.004	<.001	3	2
UCEC	FAM122B →	+0.427	+2.151	.007	.002	3	2
UCEC	SGO2 →	+0.625	+2.269	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,856 associations by consensus.

Exploration

PBX1 survival (RNA) · tumor vs normal (RNA) · all PBX1 data types