Across TCGA pan-cancer cohorts, PBX1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PBX1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PBX1 RNA is repressed in tumor relative to normal tissue. In most cancer types PBX1 is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where PBX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PBX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.595	<.001	12	view →
HNSC	Male	II,III,IV	−1.239	<.001	11	view →
KICH	Male	II,III,IV	−2.290	<.001	10	view →
COAD	Male	II,III,IV	−1.089	<.001	10	view →
UCEC	All	III,IV	−2.360	<.001	8	view →
BRCA	All	III,IV	+1.103	<.001	8	view →
KIRP	Male	All	−1.077	<.001	6	view →
THCA	All	All	−0.501	.001	6	view →
LUAD	Female	II,III,IV	−1.020	<.001	5	view →
CHOL	All	All	+1.647	<.001	4	view →
STAD	Female	All	−1.440	.002	4	view →
READ	All	All	−1.343	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

Exploration

Same gene, other analysis: PBX1 RNA expression & survival · all PBX1 data types