Across TCGA patient cohorts, PBX1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBX1-associated genes across cancer lineages are NF2, p70-S6K_pT389, and MSH6. Each is linked with PBX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PBX1-to-partner and partner-to-PBX1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX1→partner) and Y-score (partner→PBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.235	+2.321	.007	.033	3	2
UCEC	p70-S6K_pT389 →	-0.263	-2.797	<.001	.003	3	2
SKCM	MSH6 →	+0.319	+3.000	.027	.034	3	2
SKCM	Smac →	+0.278	+2.017	.021	.018	3	2
UCEC	14-3-3_beta →	-0.101	-2.432	.012	.018	3	1
UCEC	eEF2 →	+0.405	+3.087	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

PBX1 survival (RNA) · tumor vs normal (RNA) · all PBX1 data types