Across TCGA cell cohorts, PBX1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PBX1-associated genes across cancer lineages are FSHB, OPN1LW, and CLEC2A. Each is linked with PBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PBX1-to-partner and partner-to-PBX1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX1→partner) and Y-score (partner→PBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FSHB →	+0.035	+4.614	<.001	.004	3	1
LUNG_SCLC	OPN1LW →	+0.242	+5.029	<.001	.006	3	1
LUNG_SCLC	CLEC2A →	+0.129	+5.029	<.001	.006	3	1
LUNG_SCLC	OR11G2 →	+0.030	+5.643	<.001	.002	3	1
LUNG_SCLC	CLEC6A →	+0.133	+5.029	<.001	.006	3	1
BLOOD_Leukemia	SYCN →	+0.035	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

PBX1 survival (RNA) · tumor vs normal (RNA) · all PBX1 data types