Across TCGA cell cohorts, PBX1 mutation is significantly associated with the mutation status of many other genes, with 2,376 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PBX1-associated genes across cancer lineages are NRXN2, CHRM3, and SNRNP200. Each is linked with PBX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PBX1-to-partner and partner-to-PBX1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX1→partner) and Y-score (partner→PBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NRXN2 →	+5.392	+5.392	.004	.004	1	5
UPPER_AERODIGESTIVE_TRACT	CHRM3 →	+5.392	+5.392	.004	.004	1	5
SOFT_TISSUE	SNRNP200 →	+5.502	+5.502	.003	.003	1	5
SOFT_TISSUE	SEMA6D →	+4.502	+5.066	.007	.007	1	5
BLOOD_Lymphoma	GRIN3A →	+5.014	+5.584	.003	.003	1	4
LUNG_NSCLC_LUAD	CACNA1H →	+2.678	+4.342	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,376 associations by consensus.

Exploration

PBX1 survival (RNA) · tumor vs normal (RNA) · all PBX1 data types