PBX1-AS1

Across TCGA pan-cancer cohorts, PBX1-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PBX1-AS1 data layer.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher PBX1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PBX1-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and BRCA show a favorable association.

CHOL, LAML, and DLBC are the cancer types where PBX1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	DFS	Tertile	All	0.045	0.522	.001	36	view →
LAML	DFS	Quartile	All	0.711	0.509	.006	36	view →
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	34	view →
ACC	DFS	Median	All	0.423	0.759	.006	34	view →
BRCA	DFS	Median	IV	0.717	0.308	.002	27	view →
KIRP	OS	Tertile	IV	0.111	0.503	<.001	25	view →
UVM	OS	Tertile	All	1.000	0.491	.008	24	view →
KIRC	DFS	Tertile	IV	0.211	0.514	.027	18	view →
LUAD	DFS	Quartile	IV	0.102	0.700	.008	15	view →
LGG	DFS	Tertile	All	0.670	0.769	.007	15	view →
GBM	DFS	Median	All	0.161	0.346	.008	12	view →
OV	DFS	Median	III,IV	0.403	0.340	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

PBX1-AS1–CHOL (DFS)

Open the CHOL breakdown →