PBX1-AS1

Across TCGA pan-cancer cohorts, PBX1-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PBX1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where PBX1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PBX1-AS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

BRCA, THCA, and LUSC are the cancer types where PBX1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PBX1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.222	.012	4	view →
THCA	Female	All	−0.038	<.001	4	view →
LUSC	All	All	+0.049	.002	2	view →
HNSC	Male	All	+0.018	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PBX1-AS1–BRCA

Open the BRCA breakdown →