PBRM1

Across TCGA pan-cancer cohorts, PBRM1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PBRM1 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PBRM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PBRM1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where PBRM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.973	0.902	.004	30	view →
HNSC	OS	Quartile	All	0.768	0.969	.005	29	view →
PDAC	DFS	Quartile	All	0.900	0.677	.013	11	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PBRM1–LSCC (DFS)

Open the LSCC breakdown →