PBRM1

Across TCGA patient cohorts, PBRM1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,348 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PBRM1-associated proteins across cancer lineages are QRICH1, RBM15B, and TOP2B. Each is linked with PBRM1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PBRM1-to-partner and partner-to-PBRM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PBRM1 versus QRICH1 in LSCC, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PBRM1→partner) and Y-score (partner→PBRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	QRICH1 →	+0.173	+0.312	<.001	.002	3	7
HNSC	RBM15B →	+0.299	+0.420	<.001	.008	2	7
GBM	TOP2B →	+0.381	+0.434	<.001	<.001	3	5
GBM	PRPF4 →	+0.313	+0.439	<.001	<.001	3	4
LSCC	PTBP2 →	+0.764	+0.340	.005	.003	3	4
LSCC	RBM15B_S267 →	+0.259	+0.294	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,348 associations by consensus.

PBRM1 vs QRICH1 — LSCC

Explore this scatter interactively →