PBRM1

Across TCGA cell cohorts, PBRM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,933 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PBRM1-associated GO terms across cancer lineages are DNA-templated transcription elongation, Regulation of double-strand break repair via homologous recombination, and Nuclear transport. Each is linked with PBRM1 in more than 18 cancer types. Because this analysis shows association rather than direction, both PBRM1-to-partner and partner-to-PBRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription elongation grouped by PBRM1-low versus PBRM1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PBRM1→partner) and Y-score (partner→PBRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA-templated transcription elongation →	+0.088	+0.960	<.001	<.001	3	19
LUNG_SCLC	Regulation of double-strand break repair via homologous recombination →	+0.113	+1.290	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.089	+1.203	<.001	<.001	3	18
BREAST	Regulation of chromosome segregation →	+0.121	+1.234	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Nucleocytoplasmic transport →	+0.088	+1.243	<.001	<.001	3	18
SOFT_TISSUE	Regulation of DNA repair →	+0.072	+1.145	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,933 associations by consensus.

DNA-templated transcription elongation by PBRM1 expression — OESOPHAGUS

Explore this box plot interactively →