PBRM1

Across TCGA cell cohorts, PBRM1 mutation is significantly associated with the RNA expression of many other genes, with 265 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PBRM1-associated genes across cancer lineages are ADAM18, SIX2, and SCLY. Each is linked with PBRM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PBRM1-to-partner and partner-to-PBRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM18 grouped by PBRM1-low versus PBRM1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBRM1→partner) and Y-score (partner→PBRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ADAM18 →	+1.195	+2.289	<.001	.005	2	3
KIDNEY	SIX2 →	+0.797	+2.584	<.001	.001	3	2
LARGE_INTESTINE	SCLY →	+0.502	+2.628	.008	.002	3	2
BREAST	C1orf185 →	+0.040	+4.196	<.001	.006	3	2
KIDNEY	EEF1A2 →	-3.773	-3.169	<.001	<.001	3	1
KIDNEY	FBXO3 →	-0.374	-3.000	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 265 associations by consensus.

ADAM18 by PBRM1 expression — KIDNEY

Explore this box plot interactively →