PAXX

Across TCGA patient cohorts, PAXX protein abundance is significantly associated with the RNA expression of many other genes, with 14,782 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PAXX-associated genes across cancer lineages are C9orf78, CRIP1, and FGD3. Each is linked with PAXX in more than 5 cancer types. Because this analysis shows association rather than direction, both PAXX-to-partner and partner-to-PAXX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAXX versus C9orf78 in OV, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXX→partner) and Y-score (partner→PAXX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C9orf78 →	+0.754	+0.524	<.001	<.001	3	6
BRCA	CRIP1 →	+0.727	+0.306	<.001	<.001	3	6
BRCA	FGD3 →	+1.365	+0.310	<.001	<.001	3	6
CCRCC	TRBV5-1 →	+0.708	+0.233	.005	.001	3	6
OV	ABITRAM →	+0.723	+0.468	<.001	<.001	3	5
LUAD	TRMO →	+0.501	+0.297	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,782 associations by consensus.

PAXX vs C9orf78 — OV

Explore this scatter interactively →