PAXX

Across TCGA pan-cancer cohorts, PAXX RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PAXX’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PAXX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAXX is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, BLCA, and LIHC are the cancer types where PAXX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAXX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.297	<.001	11	view →
BLCA	Male	All	+1.080	<.001	10	view →
LIHC	Female	II,III,IV	+1.234	<.001	9	view →
STAD	All	II,III,IV	+1.171	<.001	9	view →
HNSC	Male	III,IV	+1.175	<.001	8	view →
KIRP	Male	II,III,IV	+0.810	.001	8	view →
KICH	Female	All	−0.720	<.001	7	view →
BRCA	All	III,IV	+0.983	<.001	6	view →
UCEC	All	All	+0.802	<.001	6	view →
ESCA	All	II,III,IV	+2.035	<.001	5	view →
CHOL	All	All	+1.747	<.001	5	view →
READ	All	All	+0.912	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PAXX–COAD

Open the COAD breakdown →