PAXX

Across TCGA patient cohorts, PAXX protein abundance is significantly associated with the protein abundance of many other proteins, with 15,430 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PAXX-associated proteins across cancer lineages are PAXX_S152, NANS, and EDF1. Each is linked with PAXX in more than 8 cancer types. Because this analysis shows association rather than direction, both PAXX-to-partner and partner-to-PAXX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAXX versus PAXX_S152 in BRCA, with a Pearson correlation of 0.72.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXX→partner) and Y-score (partner→PAXX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PAXX_S152 →	+0.512	+0.376	<.001	<.001	3	9
HNSC	NANS →	+0.428	+0.226	<.001	.001	3	8
OV	EDF1 →	+0.503	+0.419	<.001	.001	3	7
COAD	PHPT1 →	+0.580	+0.210	<.001	<.001	3	7
BRCA	RABL6 →	+0.340	+0.359	<.001	<.001	3	7
HNSC	AKR1A1 →	+0.450	+0.287	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,430 associations by consensus.

PAXX vs PAXX_S152 — BRCA

Explore this scatter interactively →