PAXX

Across TCGA cell cohorts, PAXX RNA expression is significantly associated with the go_rna of many other GO terms, with 3,097 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PAXX-associated GO terms across cancer lineages are CTP salvage, Regulation of DNA-templated DNA replication, and Leading strand elongation. Each is linked with PAXX in more than 13 cancer types. Because this analysis shows association rather than direction, both PAXX-to-partner and partner-to-PAXX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTP salvage grouped by PAXX-low versus PAXX-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAXX→partner) and Y-score (partner→PAXX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CTP salvage →	+0.159	+0.902	<.001	<.001	3	14
BONE	Regulation of DNA-templated DNA replication →	+0.130	+1.026	<.001	<.001	3	12
BONE	Leading strand elongation →	+0.191	+1.100	.001	<.001	3	12
BONE	Nuclear DNA replication →	+0.177	+1.071	.001	<.001	3	11
BONE	Telomeric loop disassembly →	+0.134	+0.972	<.001	<.001	3	11
BONE	Positive regulation of DNA-templated DNA replication →	+0.170	+1.053	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,097 associations by consensus.

CTP salvage by PAXX expression — PANCREAS

Explore this box plot interactively →